Organic Synthesis of New Bioactive Small Molecules and Synthetic Methodology
The small molecules we screen come from multiple sources both external and internal, including small libraries and individual compounds synthesized in our lab. In addition, during the process of making molecules to support our chemical biology studies, particularly work on new small-molecule probes of cell migration and related studies, we have also explored new synthetic methodology.
Ankala, S.V.; Fenteany, G. Selective deprotection of either aryl or alkyl silyl ethers from aryl, alkyl bis-silyl ethers. Tetrahedron Lett. 2002, 43, 4729-4732. [Abstract] HTML] [PDF]
Ankala, S.V.; Fenteany, G. Aryl, alkyl bis-silyl ethers: rapid access to monoprotected aryl alkyl and biaryl ethers. Synlett 2003, 6, 825-828.[PDF]
Beshir, A.B.; Guchhait, S.K.; Gascón, J.A.; Fenteany, G. Synthesis and structure-activity relationships of metal-ligand complexes that potently inhibit cell migration. Bioorg. Med. Chem. Lett. 2008, 8, 498-504. [Abstract] [HTML] [PDF]
