Eddy, N.A.; Richardson, J.J.; Fenteany, G. The effect of Lewis acids on the cycloaddition of 3,3,6-trimethylcyclohex-5-ene-1,2,4-trione: hydrogen transfer versus cycloaddition with cyclopentadiene. Eur. J. Org. Chem. 2013, 2013 (23), 5041-5044. [Abstract] [HTML] [PDF]

Clark, A.G.; Sider, J.R.; Verbrugghe, K.; Fenteany, G.; von Dassow, G.; Bement, W.M. Identification of small molecule inhibitors of cytokinesis and single cell wound repair. Cytoskeleton 2012, 69, 1010–1020. [Abstract] [HTML] [PDF]

Rudnitskaya, A.N.; Eddy, N.A.; Fenteany, G.; Gascón, J.A. Recognition and reactivity in the binding between Raf kinase inhibitor protein and its small-molecule inhibitor locostatin. J. Phys. Chem. B. 2012, 116, 10176–10181. [Abstract] [HTML] [PDF]

Ren, G.; Baritaki, S.; Marathe, H.; Feng, J.; Park, S.; Beach, S.; Bazeley, P.S.; Beshir, A.B.; Fenteany, G.; Mehra, R.; Daignault, S.; Al Mulla, F.; Keller, E.; Bonavida, B.; de la Serna, I.; Yeung, K.C. Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer. Cancer. Res. 2012, 72, 3091-3104. [Abstract] [HTML] [PDF]

Eddy, N.A.; Kelly, C.B.; Mercadante, M.A.; Leadbeater, N.E.; Fenteany, G. Access to dienophilic ene-triketone synthons by oxidation of diketones with an oxoammonium salt. Org. Lett. 2012, 14, 498–501. [Abstract] [HTML] [PDF]

Eddy, N.A.; Morse, P.D.; Morton, M.D.; Fenteany, G. Synthesis of oxazolidinone and tosyl enamines by tertiary amine catalysis. Synlett 2011, 5, 699–701. [Abstract] [HTML] [PDF]

Beshir, A.B.; Argueta, C.E.; Menikarachchi, L.C.; Gascón, J.A.; Fenteany, G. Locostatin disrupts association of Raf kinase inhibitor protein with binding proteins by modifying a conserved histidine residue in the ligand-binding pocket. For. Immunopathol. Dis. Therap. 2011, 2, 47–58. [Abstract] [PDF]

Wang, Z.; Castellano, S.; Kinderman, S.S.; Argueta, C.E.; Beshir, A.B.; Fenteany, G.; Kwon, O. Diversity through a branched reaction pathway: generation of a library of sixteen multicyclic scaffolds and identification of antimigratory agents. Chem. Eur. J. 2011, 17, 649–654. [Abstract] [PDF]

Knecht, D.A.; LaFleur, R.; Kahsai, A.W.; Argueta, C.E.; Beshir, A.B.; Fenteany, G. Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. PLoS ONE 2010, 5, e14039. [Abstract] [HTML] [PDF]

Beshir, A.B.; Ren, G.; Magpusao, A.N.; Barone, L.M.; Yeung, K.C.; Fenteany, G. Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. Cancer Lett. 2010, 299, 137–149. [Abstract] [HTML] [PDF]

Magpusao, A.N.; Desmond, R.; Billings, K.J.; Fenteany, G.; Peczuh, M.W. Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactones. Bioorg. Med. Chem. Lett. 2010, 20, 5472–5476. [Abstract] [HTML] [PDF]

Kahsai, A.W.; Zhu, S.; Fenteany, G. G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. Biochim. Biophys. Acta - Mol. Cell Res. 2010, 1803, 300–310. [Abstract] [HTML] [PDF]

Ménoret, A.; McAleer, J.P.; Ngoi, S.-M.; Ray, S.; Eddy, N.A.; Fenteany, G.; Lee, S.-J.; Rossi, R.J.; Mukherji, B.; Allen, D.L.; Chakraborty, N.G.; Vella, A.T. The oxazolidinone derivative locostatin induces cytokine appeasement. J. Immunol. 2009, 183, 7489–7496. [Abstract] [HTML] [PDF]

Kahsai, A.W.; Cui, J.; Kaniskan, H.Ü.; Garner, P.P.; Fenteany, G. Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. J. Biol. Chem. 2008, 283, 24534–24545. [Abstract] [HTML] [PDF]

Beshir, A.B.; Guchhait, S.K.; Gascón, J.A.; Fenteany, G. Synthesis and structure–activity relationships of metal–ligand complexes that potently inhibit cell migration. Bioorg. Med. Chem. Lett. 2008, 8, 498–504. [Abstract] [HTML] [PDF]

Mc Henry, K.T.; Montesano, R.; Zhu, S.; Beshir, A.B.; Tang, H.-H.; Yeung, K.C.; Fenteany, G. Raf kinase inhibitor protein positively regulates cell-substratum adhesion while negatively regulating cell-cell adhesion. J. Cell. Biochem. 2008, 103, 972–985. [Abstract] [HTML] [PDF]

Kahsai, A.W.; Zhu, S.; Wardrop, D.J.; Lane, W.S.; Fenteany, G. Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. Chem. Biol. 2006, 13, 973–983. [Abstract] [HTML] [PDF]

Stossel, T.P.; Fenteany, G.; Hartwig, J.H. Cell surface actin remodeling. J. Cell Sci. 2006, 119, 3261–3264. [Abstract] [HTML] [PDF]

Farooqui, R.; Zhu, S.; Fenteany, G. Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration. Exp. Cell Res. 2006, 312, 1514–1525. [Abstract] [HTML] [PDF]

Zhu, S.; Mc Henry, K.T.; Lane, W.S.; Fenteany, G. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem. Biol. 2005, 12, 981–991. [Abstract] [HTML] [PDF] (This work was highlighted in Chem. Biol. 12, 953–954.)

Farooqui, R.; Fenteany, G. Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement. J. Cell Sci. 2005, 118, 51–63. [Abstract] [HTML] [PDF] (This work was highlighted in J. Cell Sci. 118, 103e and Faculty of 1000)

Altan, Z.M.; Fenteany, G. c-Jun N-terminal kinase regulates lamellipodial protrusion and cell sheet migration during epithelial wound closure by a gene expression-independent mechanism. Biochem. Biophys. Res. Commun. 2004, 322, 56–67. [Abstract] [HTML] [PDF]

Fenteany, G.; Glogauer, M. Cytoskeletal remodeling in leukocyte function. Curr. Opin. Hematol. 2004, 11, 15–24. [Abstract] [HTML] [PDF]

Ankala, S.V.; Fenteany, G. Aryl, alkyl bis-silyl ethers: rapid access to monoprotected aryl alkyl and biaryl ethers. Synlett 2003, 6, 825–828.[PDF]

Fenteany, G.; Zhu, S. Small-molecule inhibitors of actin dynamics and cell motility. Curr. Topics Med. Chem. 2003, 3, 593–616. [Abstract] [PDF]

Mc Henry, K.T.; Ankala, S.V.; Ghosh, A.K.; Fenteany, G. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. ChemBioChem 2002, 11, 1105–1111. [Abstract] [HTML] [PDF] (This work was highlighted in Trends Biochem. Sci. 27, 605, Drug Discovery Today 8, 6-7 and Faculty of 1000)

Ankala, S.V.; Fenteany, G. Selective deprotection of either aryl or alkyl silyl ethers from aryl, alkyl bis-silyl ethers. Tetrahedron Lett. 2002, 43, 4729–4732. [Abstract] HTML] [PDF]

Fenteany, G.; Janmey, P.A.; Stossel, T.P. Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr. Biol. 2000, 10, 831–838. [Abstract] [HTML] [PDF]

Corey, E.J.; Li, W.Z.; Nagamitsu, T.; Fenteany, G. The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs. Tetrahedron 1999, 55, 3305–3316. [Abstract] [PDF]

Fenteany, G.; Schreiber, S.L. Lactacystin, proteasome function, and cell fate. J. Biol. Chem. 1998, 273, 8545-8548. [HTML] [PDF]

Degnan, B.M.; Degnan, S.M.; Fenteany, G.; Morse, D.E. A Mox homeobox gene in the gastropod mollusc Haliotis rufescens is differentially expressed during larval morphogenesis and metamorphosis. FEBS Lett. 1997, 411, 119–122. [Abstract] [PDF]

Craiu, A.; Gaczynska, M.; Akopian, T.; Gramm, C.F.; Fenteany, G.; Goldberg, A.L.; Rock, K.L. Lactacystin and clasto-lactacystin β-lactone modify multiple proteasome β-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J. Biol. Chem. 1997, 272, 13437–13445. [Abstract] [HTML] [ PDF]

Fenteany, G.; Schreiber, S.L. Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells. Chem. Biol. 1996, 3, 905–912. [Abstract] [PDF]

Fenteany, G.; Standaert, R.F.; Lane, W.S.; Choi, S.; Corey, E.J.; Schreiber, S.L. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 1995, 268, 726–731. [Abstract] [HTML] [PDF]

Fenteany, G.; Standaert, R.F.; Reichard, G.A.; Corey, E.J.; Schreiber, S.L. A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc. Natl. Acad. Sci. USA 1994, 91, 3358–3362. [Abstract] [PDF]

Fenteany, G.; Morse, D.E. Specific inhibitors of protein synthesis do not block RNA synthesis or settlement of planktonic larvae in a marine gastropod mollusc (Haliotis rufescens). Biol. Bull. 1993, 184, 6–14. [Abstract] [PDF]

 

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