Cell Cycle and Cytokinesis

Cell Cycle Regulation and the Control of Cell Proliferation (Cell Growth + Cell Division)

• Cell Cycle Research - General resource with links to relevant recent literature, news and job listings. (Ion Channel Media Group)
• The Eukaryotic Cell Cycle and Cancer - Introduction to the eukaryotic cell cycle as it relates to the genetics of cancer. (Phillip McClean, North Dakota State University) (Just above Beginner's Level)
• ICRF FACS Laboratory Cell Cycle Analysis - Methods for cell cycle analysis using flow cytometry. (FACS Laboratory, Imperial Cancer Research Fund, UK)
• The Interactive Fly: Evolutionarily Conserved Pathways (Society for Developmental Biology). Includes sections on:
  • Cell Cycle 1: Replication - "Replication Licensing Factor (RLF) and Origin Replication Complex (ORC)."
  • Cell Cycle 2: The G1-S Transition - "Involvement of E2F, cyclin D, cyclin E and retinoblastoma protein."
  • Cell Cycle 3: The G2-M Transition - "Cyclin A, cyclin B, cdc2, Wee kinase and cdc25 phosphatase."
• Kimball's Biology Pages: The Cell Cycle - Basic information on the cell cycle (G1 = Gap 1 phase, growth and preparation of the chromosomes for replication; S = synthesis of DNA and centrioles; G2 = Gap 2, preparation for M = mitosis). (Beginner's Level)
• Kyoto Encyclopedia of Genes and Genomes (KEGG) - Includes graphical and hypertext-based information on biochemical pathways, including metabolic and regulatory pathways (for instance, cell cycle and growth factor signaling).
• NPG Web Focus: Cell Division (Nature Publishing Group)
• The Ubiquitin System for Protein Modification and Degradation - A broad range of information on the ubiquitin/proteasome pathway, the proteolytic system that helps control cell cycle progression by the regulated degradation of cell cycle proteins like the cyclins.
• Wikipedia - Free online encyclopedia with basic overviews. (Beginner's Level)
  • Cell Cycle
  • Cell Growth
  • Cell Division
• Yeast Cell Cycle Analysis Project - The goal of this project is to identify all genes whose mRNA levels are regulated by the cell cycle.

See also the Apoptosis, Cell Senescence and Signal Transduction pages.

Mitosis, Meiosis and the Mechanics of Cell Division

• The Biology Project - Tutorials, lessons and quizzes on basic biology. (University of Arizona) (Beginner's Level)
  • Cell Biology: The Cell Cycle and Mitosis Tutorial
  • Cell Biology: Meiosis Tutorial
• The Cytokinetic Mafia - Web site devoted to cytokinesis.
• MIT Biology Hypertextbook: Mitosis - Tutorial on mitosis. (Beginner's Level)
• Mitosis World - Resources for people studying mitosis.
• Plant Cytokinesis - Information on and mages of cytokinesis in plants. (Chun-Ming Liu, Plant Research International, Wageningen, The Netherlands)
• Plant Mitosis - Information on and mages of mitosis in plants. (Chun-Ming Liu, Plant Research International, Wageningen, The Netherlands)
• On-Line Biology Book - Comprehensive introduction to biology at the "college freshman" level by M.J. Farabee. (Beginner's Level)
  • Cell Division: Binary Fission and Mitosis
  • Cell Division: Meiosis and Sexual Reproduction
• A Web Atlas of Cellular Structures: Stages of Mitosis - Confocal microscope images of cells in different stages of mitosis with brief text descriptions. (Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana-Champaign) (Just above Beginner's Level)
• Wikipedia - Free online encyclopedia with basic overviews. (Beginner's Level)
• Meiosis
• Mitosis

See also the Cytoskeleton, Cell Motility and Motors page.

Cancer Resources

A major component of cancer progression is the loss of normal controls on cell proliferation (disruption of normal cell cycle regulation and cell signaling), in addition to other changes involving angiogenesis, cell adhesion, invasion and metastasis. There exist many resources and gateways to cancer information on the Web, including:

• American Cancer Society
  • All About Cancer: Information Guide
  • Glossary Search
  • Guide to Cancer Drugs
  • Online Continuing Medical Education
• CancerGuide: Cancer Basics - Basic information on cancer and links to more specialized resources dealing with individual types of cancer. (Steve Dunn) (Beginner's Level)
• Cancer Helper - Basic information on cancer. (Beginner's Level)
• Cancer Research UK - Science and Research - "On this page you will find links to other CR-UK Science and Research web pages including our Scientific Reports and application procedures."
• Categories of Cancer/Cancer Classification
• Kimball's Biology Pages - A comprehensive online biology textbook. (Beginner's Level)
  • Cancer - Basic information on cancer.
  • Oncogenes - Tutorial on oncogenes, the cancer-promoting form of positive growth control genes.
  • Tumor Suppressor Genes - Tutorial on tumor suppressor genes (anti-oncogenes).
• National Cancer Institute (NCI)
  • Cancer.gov - NCI's comprehensive cancer information resource.
• Cancer Facts - A "collection of fact sheets that address a variety of cancer topics."
• Dictionary of Cancer Terms
• Understanding Cancer Series - Slide-based overviews of cancer, the immune system, cancer genomics, angiogenesis , estrogen receptor/SERMs, genetic variation (SNPs), gene testing, cancer genome project and nanodevices.
• Nova Online: Cancer Warrier: How Cancer Grows (Beginner's Level)
• The Medical Biochemistry Page - An excellent biochemistry tutorial with information on a broad range of biochemical pathways. (Michael W. King, Terre Haute Center for Medical Education, Indiana University School of Medicine)
  • Oncogenes and Cancer
  • Tumor Suppressors and Cancer
• OncoLink - Large cancer resource site. (Abramson Cancer Center of the University of Pennsylvania)
• Open Directory: Health: Conditions and Diseases: Cancer
• The p53 Web Site - A range of resources related to the p53 tumor suppressor and cancer.
• Wikipedia - Free online encyclopedia with basic overviews. (Beginner's Level)
  • Adenoma
  • Astrocytoma
  • Cancer
  • Carcinoma
  • Leukemia
  • Lymphoma
  • Melanoma
  • Multiple Myeloma
  • Oncogene
  • Oncology
  • p53
  • Prostate Cancer
  • Retinoblastoma
  • Sarcoma
  • Teratoma
  • Thymoma
  • Tumor
  • Tumor Suppressor Gene
• Yahoo: Health: Diseases and Conditions: Cancer

See also the Tumor Cell Invasion and Metastasis section of the Cytoskeleton, Cell Motility and Motors page and the Angiogenesis, Cell Adhesion and Extracellular Matrix and Signal Transduction pages.

Discussion Groups

• BioChemWeb.org Discussion Board - Discussions and questions/answers for scientists and students.
• RADONCJC/prototype - Disemmination and discussion of literature relating to radiation oncology. (Usenet newsgroup archives from BIOSCI/bionet; can also be accessed through Google Groups: bionet)

See also the Discussion Groups section of the General Biochemistry and Cell Biology page.

Labs Studying Cell Cycle or Cytokinesis